definition of phagocytosis involves the engulfment and degradation of large solid particles, initiated by receptor activation on phagocytes. It forms an essential aspect of innate immunity through the uptake and destruction of infectious pathogens, while also participating in the removal of apoptotic cells during tissue remodeling and development. Professional phagocytes, such as macrophages, neutrophils, and dendritic cells, are well equipped with a wide range of phagocytic receptors. In addition, these specialized leukocytes can signal to lymphocytes within the adaptive arm of host immunity. This review emphasizes the role of two well-characterized opsonic receptors, the Fcy receptor and the complement receptor, CR3 in macrophages. In particular, it focuses on the different mechanisms employed by these receptors during particle recognition and phagocytic uptake. Bacterial species often manipulate phagocyte signaling in order to evade their engulfment and degradation and consequently provide further insight into key regulators of the phagocytic process. Finally, we draw attention to the physiological relevance of studying the simultaneous engagement of multiple phagocytic receptors, in order to better understand receptor crosstalk and the underlying coordination of downstream signaling for efficient phagocytosis. Table of Contents: Phagocytosis / Innate Immunity: Target Cell Recognition and Binding / Modes of Uptake: FcyR(Type I)-Mediated Phagocytosis and Pseudopod Extension / Modes of Uptake: CR3 (Type II)-Mediated Phagocytosis and Ruffle Formation / FcyR and CR3-Mediated Phagocytosis: Cytoskeletal Involvement / Membrane Contributions to Pseudopod Formation / Phagosome Maturation / Phagocytosis of Bacteria / Adaptive Immunity: Antigen Presentation / Tissue Remodeling: Phagocytosis of Apoptotic Cells / Concluding Remarks: Other Phagocytes and the Coordination of FcyR and CR3 Signaling in Phagocytosis / References / Author Biographies

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