early onset, greater extent, and increased risk of metabolic disorders (e.g., diabetes, obesity, hyperlipidemia); new approaches to treatment; and new guidelines for management of blood glucose, cholesterol, and body weight. The author concentrates on basic principles of endocrine pathophysiology, illustrates their significance with clinical problems, and provides a framework for solving problems rather than focusing on details of treatment, which change constantly. Review questions and answers are provided for self-assessment.

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