modeling and offers a wide range of possible applications. Marginal models are often the best choice for answering important research questions when dependent observations are involved, as the many real world examples in this book show. In the social, behavioral, educational, economic, and biomedical sciences, data are often collected in ways that introduce dependencies in the observations to be compared. For example, the same respondents are interviewed at several occasions, several members of networks or groups are interviewed within the same survey, or, within families, both children and parents are investigated. Statistical methods that take the dependencies in the data into account must then be used, e.g., when observations at time one and time two are compared in longitudinal studies. At present, researchers almost automatically turn to multi-level models or to GEE estimation to deal with these dependencies. Despite the enormous potential and applicability of these recent developments, they require restrictive assumptions on the nature of the dependencies in the data. The marginal models of this book provide another way of dealing with these dependencies, without the need for such assumptions, and can be used to answer research questions directly at the intended marginal level. The maximum likelihood method, with its attractive statistical properties, is used for fitting the models. This book has mainly been written with applied researchers in mind. It includes many real world examples, explains the types of research questions for which marginal modeling is useful, and provides a detailed description of how to apply marginal models for a great diversity of research questions. All these examples are presented on the book's website (www.cmm.st), along with user friendly programs.

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