biologists, geneticists, enzymologists, crystallographers, chemists and physicists. To observe these machines in action, researchers have developed entirely new methodologies for the detection and the nanomanipulation of single molecules. This book, written by expert scientists in the field, analyses how these diverse fields of research interact on a specific example - RNA polymerases. RNA polymerases play a central role among all the other machines operating in the cell and are the target of a wide range of regulatory mechanisms and have also been the subject of spectacular advances in their structural understanding in recent years.

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