science. The case histories illustrate essential points about the mechanisms of immunity and describe immunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case. Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway’s Immunobiology, Eighth Edition. A marginal icon in Janeway’s Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting. The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includes ten new cases: DiGeorge Syndrome Hemophagocytic Lymphohistiocytosis Chediak-Higashi Syndrome Hyper IgE Syndrome Ataxia Telangiectasia Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) Syndrome Severe Congenital Neutropenia Recurrent Herpes Simplex Encephalitis Systemic Onset Juvenile Idiopathic Arthritis Crohn’s Disease

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