1979 and 2000, and–together withVolume 41–provides a complete, up-to-date reference forheterocyclic chemists. It emphasizes practical approaches topyrazine chemistry, offers a full appendix of all simple pyrazinesup to 2000, and features detailed coverage of the following topics:Systematic descriptions of all primary synthetic routes topyrazinesOther preparative routes to alkylpyrazines and theirreactionsHalogenopyrazines and their synthetic usesOxypyrazines and trivial names for pharmaceutical oragrochemical pyrazinesThiopyrazinesAmino-, nitro-, and other similar pyrazines and theirreactionsPyrazinecarboxylic acids and their derivativesThe supplement features extensive cross-references to theoriginal volume and uses chemical nomenclature as per current IUPACrecommendations

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