based on this simple gene-phenotype approach.The alternative approach is to incorporate information about theenvironment. A gene-environment interaction approach assumes thatenvironmental pathogens cause disorder, whereas genes influencesusceptibility to environmental pathogens. This book brings together contributions from experts frommultiple disciplines who discuss:How epidemiological cohort studies can better integratephysiological (mechanistic) measures;How best to characterise subjects’ vulnerability versusresilience by moving beyond single genetic polymorphisms;How gene hunters can benefit from recruiting samples selectedfor known exposures;How environmental pathogens can be used as tools for genehunting;How to deal with potential spurious (statistical) interactions,andHow genes can help explain fundamental demographic propertiesof disorders (e.g. sex distribution, age effects).

Hide more