authors offer a uniquely balanced coverage of classical and contemporary approaches, basic and clinical aspects. As with the previous editions, the strength of the text is in a complete review of modern immunology without burdening the reader with excessive data or theoretical discussions. Each chapter is divided into short, self-contained units that address key topics illustrated by uniformly drawn, full-color illustrations, many brand new to this edition. The sixth edition of this successful textbook newly covers: Toll-like receptors, their ligands and intracellular activation pathways The key role of activation induced cytidine deaminase (AID) in somatic hypermutation and class switch recombination. The autoimmune regulator (AIRE) gene in self-tolerance and autoimmunity T and B cell activation and the immunological synapse, as well as characterization and mechanisms of action of T regulatory cells The companion website at www.wiley.com/college/coico features problem sets, quizzes, and a list of relevant internet resources. Praise for the previous edition: "This book is clearly a precious resource for undergraduate, graduate and medical students alike… For those who need an introduction to the fascinating world of immunology, this book should most certainly spark the interest." ANNALS OF BIOMEDICAL ENGINEERING "… an excellent beginner's guide… the authors have done a terrific job of providing an overview of the field." YALE JOURNAL OF BIOLOGY AND MEDICINE

Hide more