in the nervous system, and human behavior. By examining human drug use from historical, societal, and biological perspectives, Grilly provides a rich foundation for understanding drugs affecting the brain and their usage. In addition to describing basic pharmacological principles, Grilly discusses the general factors behind drug tolerance, dependence, and abuse and approaches for dealing with these problems. Pharmacotherapy for the major mental disorders is described from both biochemical and clinical efficacy perspectives.  By using the most up-to-date research, and by presenting data in concise, jargon-free prose, the author has created one of the most comprehensive and accessible books on the subject.

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