cavity to the gas exchange region. This section conveys the structural heterogeneity of the respiratory system and how it determines tissue and cellular targets for toxic agents. The next section describes functional and biochemical responses of the lungs to toxic insult and includes chapters on carcinogenic and developmental responses to chemical exposure. The final section comprises over 20 chapters describing injurious effects of selected chemicals of toxicologic interest. Human health concerns as well as mechanisms of toxicity are emphasized. Unlike other volumes that have treated this subject, attention is devoted to effects of toxic agents on both the airways and the pulmonary vasculature.

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